Assay
Age
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Immunohistochemistry (section)
Postnatal
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Mafa MAF bZIP transcription factor A (Synonyms: RIPE3b1) | |
Results | Reference |
1 | J:338878 Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L, Major beta cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes Dev. 2023 Jun 1;37(11-12):490-504 |
1 | J:169626 Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J, Magnuson MA, Stein R, MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes. 2010 Oct;59(10):2530-9 |
1 | J:236317 Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschop M, Machicao F, Staiger H, Haring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H, Identification of proliferative and mature beta-cells in the islets of Langerhans. Nature. 2016 Jul 21;535(7612):430-4 |
1 | J:301635 Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, Lickert H, Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic beta-cells. Mol Metab. 2017 Jun;6(6):524-534 |
1 | J:228228 Bonnavion R, Teinturier R, Jaafar R, Ripoche D, Leteurtre E, Chen YJ, Rehfeld JF, Lepinasse F, Hervieu V, Pattou F, Vantyghem MC, Scoazec JY, Bertolino P, Zhang CX, Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors. Mol Cell Biol. 2015 Oct;35(19):3274-83 |
1 | J:157721 Bourane S, Garces A, Venteo S, Pattyn A, Hubert T, Fichard A, Puech S, Boukhaddaoui H, Baudet C, Takahashi S, Valmier J, Carroll P, Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling. Neuron. 2009 Dec 24;64(6):857-70 |
1 | J:200985 Cai EP, Wu X, Schroer SA, Elia AJ, Nostro MC, Zacksenhaus E, Woo M, Retinoblastoma tumor suppressor protein in pancreatic progenitors controls alpha- and beta-cell fate. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14723-8 |
1 | J:129103 Chao CS, Loomis ZL, Lee JE, Sussel L, Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol. 2007 Dec 15;312(2):523-32 |
1 | J:235909 Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT Jr, Powers AC, Gu G, Stein R, The MAFB transcription factor impacts islet alpha-cell function in rodents and represents a unique signature of primate islet beta-cells. Am J Physiol Endocrinol Metab. 2016 Jan 1;310(1):E91-E102 |
1 | J:199303 Diaferia GR, Jimenez-Caliani AJ, Ranjitkar P, Yang W, Hardiman G, Rhodes CJ, Crisa L, Cirulli V, beta1 integrin is a crucial regulator of pancreatic beta-cell expansion. Development. 2013 Aug;140(16):3360-72 |
1 | J:296539 Helman A, Cangelosi AL, Davis JC, Pham Q, Rothman A, Faust AL, Straubhaar JR, Sabatini DM, Melton DA, A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion. Cell Metab. 2020 May 5;31(5):1004-1016.e5 |
1 | J:154990 Kang HS, Kim YS, ZeRuth G, Beak JY, Gerrish K, Kilic G, Sosa-Pineda B, Jensen J, Foley J, Jetten AM, Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. Mol Cell Biol. 2009 Dec;29(24):6366-79 |
1 | J:208336 Kesavan G, Lieven O, Mamidi A, Ohlin ZL, Johansson JK, Li WC, Lommel S, Greiner TU, Semb H, Cdc42/N-WASP signaling links actin dynamics to pancreatic beta cell delamination and differentiation. Development. 2014 Feb;141(3):685-96 |
1 | J:287368 Kim-Muller JY, Fan J, Kim YJ, Lee SA, Ishida E, Blaner WS, Accili D, Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic beta cells in diabetic mice. Nat Commun. 2016 Aug 30;7:12631 |
1 | J:250031 Kodama S, Nakano Y, Hirata K, Furuyama K, Horiguchi M, Kuhara T, Masui T, Kawaguchi M, Gannon M, Wright CV, Uemoto S, Kawaguchi Y, Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice. Sci Rep. 2016 Feb 18;6:21211 |
1 | J:325444 Lecoin L, Dempsey B, Garancher A, Bourane S, Ruffault PL, Morin-Surun MP, Rocques N, Goulding M, Eychene A, Pouponnot C, Fortin G, Champagnat J, Mafa-dependent GABAergic activity promotes mouse neonatal apneas. Nat Commun. 2022 Jun 7;13(1):3284 |
1 | J:234890 Li F, Su Y, Cheng Y, Jiang X, Peng Y, Li Y, Lu J, Gu Y, Zhang C, Cao Y, Wang W, Ning G, Conditional deletion of Men1 in the pancreatic beta-cell leads to glucagon-expressing tumor development. Endocrinology. 2015 Jan;156(1):48-57 |
1 | J:186115 Lu J, Hamze Z, Bonnavion R, Herath N, Pouponnot C, Assade F, Fontaniere S, Bertolino P, Cordier-Bussat M, Zhang CX, Reexpression of oncoprotein MafB in proliferative beta-cells and Men1 insulinomas in mouse. Oncogene. 2012 Aug 2;31(31):3647-54 |
1 | J:236958 Lu J, Herrera PL, Carreira C, Bonnavion R, Seigne C, Calender A, Bertolino P, Zhang CX, Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development. Gastroenterology. 2010 May;138(5):1954-65 |
1 | J:227268 Malenczyk K, Keimpema E, Piscitelli F, Calvigioni D, Bjorklund P, Mackie K, Di Marzo V, Hokfelt TG, Dobrzyn A, Harkany T, Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6185-94 |
1 | J:208967 Mazur MA, Winkler M, Ganic E, Colberg JK, Johansson JK, Bennet H, Fex M, Nuber UA, Artner I, Microphthalmia transcription factor regulates pancreatic beta-cell function. Diabetes. 2013 Aug;62(8):2834-42 |
1* | J:108721 Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, Sharma A, A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol. 2006 May 15;293(2):526-39 |
1 | J:239946 Pan FC, Brissova M, Powers AC, Pfaff S, Wright CV, Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing beta-cells to a delta-like fate and reveals a facultative proliferative capacity in aged beta-cells. Development. 2015 Nov 01;142(21):3637-48 |
1 | J:335234 Parveen N, Wang JK, Bhattacharya S, Cuala J, Singh Rajkumar M, Butler AE, Wu X, Shih HP, Georgia SK, Dhawan S, DNA methylation Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic beta-cell Heterogeneity. Diabetes. 2023 Jan 6;72(5):575-89 |
1 | J:246400 Paul L, Walker EM, Drosos Y, Cyphert HA, Neale G, Stein R, South J, Grosveld G, Herrera PL, Sosa-Pineda B, Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine beta-Cells. Diabetes. 2016 Mar;65(3):687-98 |
1 | J:208938 Reinert RB, Brissova M, Shostak A, Pan FC, Poffenberger G, Cai Q, Hundemer GL, Kantz J, Thompson CS, Dai C, McGuinness OP, Powers AC, Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets. Diabetes. 2013 Dec;62(12):4154-64 |
1 | J:291600 Rodriguez-Seguel E, Villamayor L, Arroyo N, De Andres MP, Real FX, Martin F, Cano DA, Rojas A, Loss of GATA4 causes ectopic pancreas in the stomach. J Pathol. 2020 Apr;250(4):362-373 |
1 | J:107099 Smart NG, Apelqvist AA, Gu X, Harmon EB, Topper JN, MacDonald RJ, Kim SK, Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus. PLoS Biol. 2006 Feb;4(2):e39 |
1 | J:245178 Spaeth JM, Gupte M, Perelis M, Yang YP, Cyphert H, Guo S, Liu JH, Guo M, Bass J, Magnuson MA, Wright C, Stein R, Defining a Novel Role for the Pdx1 Transcription Factor in Islet beta-Cell Maturation and Proliferation During Weaning. Diabetes. 2017 Nov;66(11):2830-2839 |
1 | J:183890 Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D, Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet. 2012 Apr;44(4):406-12, S1 |
1 | J:187963 Talchai C, Xuan S, Lin HV, Sussel L, Accili D, Pancreatic beta Cell Dedifferentiation as a Mechanism of Diabetic beta Cell Failure. Cell. 2012 Sep 14;150(6):1223-34 |
1 | J:246477 Talchai SC, Accili D, Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult beta-Cell Mass and Function. Diabetes. 2015 Aug;64(8):2868-79 |
1 | J:339475 Toren E, Kepple JD, Coutinho KV, Poole SO, Deeba IM, Pierre TH, Liu Y, Bethea MM, Hunter CS, The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity. Mol Metab. 2023 Aug 1;76:101785 |
1 | J:129652 Vuguin PM, Kedees MH, Cui L, Guz Y, Gelling RW, Nejathaim M, Charron MJ, Teitelman G, Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation. Endocrinology. 2006 Sep;147(9):3995-4006 |
1 | J:157959 Wang S, Yan J, Anderson DA, Xu Y, Kanal MC, Cao Z, Wright CV, Gu G, Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. Dev Biol. 2010 Mar 1;339(1):26-37 |
1* | J:127471 Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G, Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910 |
1 | J:296911 Wang Y, Sun J, Lin Z, Zhang W, Wang S, Wang W, Wang Q, Ning G, m(6)A mRNA Methylation Controls Functional Maturation in Neonatal Murine beta-Cells. Diabetes. 2020 Aug;69(8):1708-1722 |
1 | J:280793 Wang Y, Sun J, Ni Q, Nie A, Gu Y, Wang S, Zhang W, Ning G, Wang W, Wang Q, Dual Effect of Raptor on Neonatal beta-Cell Proliferation and Identity Maintenance. Diabetes. 2019 Oct;68(10):1950-1964 |
1 | J:181639 Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, Reuter K, Munier FL, Carroll P, Lewin GR, Birchmeier C, The transcription factor c-Maf controls touch receptor development and function. Science. 2012 Mar 16;335(6074):1373-6 |
1 | J:289313 Xiafukaiti G, Maimaiti S, Ogata K, Kuno A, Kudo T, Shawki HH, Oishi H, Takahashi S, MafB Is Important for Pancreatic beta-Cell Maintenance under a MafA-Deficient Condition. Mol Cell Biol. 2019 Sep 1;39(17) |
1* | J:201764 Yamamoto K, Matsuoka TA, Kawashima S, Takebe S, Kubo N, Miyatsuka T, Kaneto H, Shimomura I, A novel function of Onecut1 protein as a negative regulator of MafA gene expression. J Biol Chem. 2013 Jul 26;288(30):21648-58 |
1 | J:293336 Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G, Coregulator Sin3a Promotes Postnatal Murine beta-Cell Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response. Diabetes. 2020 Jun;69(6):1219-1231 |
1 | J:177082 Yang Y, Chang BH, Yechoor V, Chen W, Li L, Tsai MJ, Chan L, The Kruppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice. Diabetologia. 2011 Oct;54(10):2595-605 |
1 | J:238418 Yang YP, Magnuson MA, Stein R, Wright CV, The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal beta-cell maturation. Development. 2017 Jan 15;144(2):248-257 |
1 | J:174673 Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV, Context-specific {alpha}-to-{beta}-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011 Aug 15;25(16):1680-5 |
1* | J:155058 Zhang H, Ables ET, Pope CF, Washington MK, Hipkens S, Means AL, Path G, Seufert J, Costa RH, Leiter AB, Magnuson MA, Gannon M, Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev. 2009 Dec;126(11-12):958-73 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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